Organizers: L. Barbeito, P. Cassina, N. Lago, S. Olivera, H. Peluffo
PROGRAM
April 3rd
13:00-14:00: Accreditation
Introductory lectures:
14:00-14:30: Metabolic interaction between neurons and glial cells. (Patricia Cassina, Facultad de Medicina UdelaR, Uruguay)
14:30-15:00: Microglia and myeloid cells in the CNS: new methodologies to identify different phenotypes (Hugo Peluffo, Facultad de Medicina, IPMont, Uruguay)
15:30-16:00: Neuroinflammation in acute CNS and PNS trauma (Natalia Lago, IPMont, Uruguay)
-----------------------------------16:00-16:30 Coffee Break----------------------------------
16:30-17:00: Glial cells and aberrant glial phenotypes in neurodegeneration (Luis Barbeito, IPMont, Uruguay)
17:00-17:30: Oligodendrocytes as vulnerable targets of neuroinflammation. (Silvia Olivera, IIBCE, Uruguay)
Thursday April 4th
Session 1: Mediators of neuroinflammation I
Moderator: Hugo Peluffo
9:00-9:40 Alterations in CD300f immunoreceptor are associated with major depressive disorder in mice and humans(Hugo Peluffo, Fmed, IPMont, Uruguay)
9:40-10:20 Aging and neuroinflammation in neurodegeneratives diseases (Rommy von Bernhardi, PUCC, Chile)
-----------------------------------10:20-11:00 Coffee Break----------------------------------
11:00-11:40 Can we boost CNS repair by stimulating anti- inflammatory macrophages? (Rubèn López-Vales, UAB, España)
11:40-12:20 The role of the immune system in the generation of neuropathic pain.
(Margarita Calvo, PUCC, Chile).
-----------------------------------12:20-14:00 Almuerzo---------------------------------------
Session 2: Mediators of neuroinflammation II
Moderator: Natalia Lago
14:00-14:40 Finding Parkinson´s disease related genes studying neuroinflammation (Fernando Pitossi, Instituto Leloir, Argentina)
14:40-15:20 Glial cells as main actors in an experimental model of Parkinson disease (Silvia Olivera, IIIBCE, Uruguay).
15:20-15:50 Pericyte response to glutaric acid and astrocyte-conditioned media (Eugenia Isasi, IIBCE-FMed, Uruguay)
---------------------15:50-16:30 Coffe break and poster sesión ----------------------
16:30-17:10 The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease (Felipe CourtUniversidad Mayor, Chile)
17:10-17:40 Potential role of alpha-Synuclein in neuroinflammation (José Souza, FMed, Uruguay)
Friday April 5th
Session 3 Neuroinflammation in ALS
Moderator: Luis Barbeito
9:00-9:40: Contrasting role of the immune response in the central and peripheral nervous system in the ALS models. (Caterina Bendotti, IRFMN, Italy)
9:40-10:20 Glial cells and the emerging concept of neuroprogression in ALS. Luis Barbeito IPMont, Uruguay
---------------------10:20-10:50 Coffe break ------------------------
10:50-11:30 Interleukin 37: a novel cytokine that confers protection against ALS. (Rubèn López-Vales, UAB, España)
11:30-12:10 Novel lipidomic markers and therapeutic potential of nitro-fatty acids in ALS. (Homero Rubbo, Fmed, Uruguay).
12:10-12:40 Significance of peripheral nervous system inflammation in ALS paralysis progression: therapeutic implications (Emiliano Trías, IPMont, Uruguay)
-----------------------------------12:40-14:00 Almuerzo---------------------------------------
Session 4 Astrocytes in neuroinflammation
Moderator: Patricia Cassina
14:00-14:40 Astrocytes and the TGF-?1 Pathway in the Healthy and Diseased Brain: a Double-Edged Sword. (Flavia Gomes, UFRJ, Brazil).
14:40-15:20 Astrocytes as active players in brain neuroinflammation: Lessons from ischemia, TBI and epilepsy (Javier Ramos, UBA Argentina)
15:20-15:50 Metabolic modulation of glial cells in ALS models (Laura Martínez-Palma, Fmed, Uruguay)
----------------------15:50-16:30 Coffe break-and Poster session----------------------
16:30-17:00 Astrocyte neuron communication by extracellular vesicles (Soledad Marton, FMed, Uruguay)
17:00-17:40 Pro-regenerative effect of glial exosomes and its modulation by transcriptional programs (Felipe Court, Universidad Mayor, Chile)
17:40-18:30 Concluding remarks
Saturday April 6th
9:00-10:30: 10 min Students presentations
---------------------10:30-10:50 Coffe break ------------------------
10:50-11:50 10 min Students presentations
11:50-12:15 Hands on groups distribution and seminar instructions
Monday 8th-Tuesday 9th
Hands on 9:00 – 16:00
5 groups of 3-4 students
1) Evaluation of metalloprotease activity in the ALS experimental model SOD1G93A rats. (Silvia Olivera/Marta Marco)
2) Identification of Inflammatory mediators by qPCR in ALS models (Soledad Marton).
3) Analysis of glial reactivity in pain and ALS models (Laura Martinez/ Valentina Lagos/ Ernesto Miquel)
4) Identification of different cell populations after Spinal Cord Injury by flow cytometry (Natalia Lago)
5) Analysis of peripheral nervous system pathology in a murine model of motor neuron disease. (Sofía Ibarburu)
Wednesday 10th
9:00-10:30 Hands on results and manuscripts presentation by the different student´s groups
Round table - Closing
