Summary
The field of mitochondrial biology has experienced rapid advnacements in recent years, both conceptually and methodologically, requiring ongoing updates. The intricate processes of mitochondrial dynamics, biogenesis and autophagy play critical roles in mitochondrial quality control and function, while their interactions with other organelles pose new challenges to researchers in this area. Additionally, the significant impact of mitochondrial metabolism and redox status on cell signaling in both physiological and pathological contexts underscore the organelle's importance as a key determinant of health and a promising target for therapeutic intervention. This symposium seeks to address the growing demand from researchers and graduate students in the biomedical field, providing essential insights and knowledge in this area of study.
Invited speakers
- Dr. César Cárdenas
Center for Integrative Biology, Faculty of Sciences, Universidad Mayor and Geroscience Center for Brain Health and Metabolism Santiago, Chile
Department of Chemistry and Biochemistry, University of California Santa Barbara, and Buck Institute for Research on Aging, Novato, USA - Dr. Natalia de Isla
Biopôle de l’Université de Lorraine, Faculté de Médecine, Ingénierie Moléculaire, Cellulaire et Physiopathologie (IMOPA), Centre national de la recherche scientifique (CNRS), Nancy, France - Dr. Nadine Hempel
Department of Medicine, Division of Hematology & Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA - Dr. Diana Jurk
Department of Physiology Biomedical Engineering, and Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA - Dr. Joao Passos
Department of Physiology and Biomedical Engineering and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA - Dr. Janine Santos
Mechanistic Toxicology Branch, Division of Translational, Toxicology, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Durham, North Carolina, USA - Dr. Javier Santos
Instituto de Biociencias, Biotecnología y Biología Translacional, Facultad de Ciencias Exactas, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
Supporting Institutions
Programa en Alimentos y Salud Humana (PAyS), Centro de Investigaciones Biomédicas (CEINBIO), Departamento de Bioquímica de la Facultad de Medicina, Programa para la Investigación Biomédica (Pro.In.Bio), Comisión Sectorial de Investigación Científica (CSIC), Universidad de la República; Programa de Desarrollo de las Ciencias Básicas (PEDECIBA); Agencia Nacional de Investigación e Innovación (ANII); Centro Latinoamericano de Biotecnología (CABBIO); Programa ECOS-Sud Uruguay-Francia; Society for Redox Biology and Medicine (SfRBM).
Venue
Sala Idea Vilariño, Torre de las Telecomunicaciones de ANTEL (Guatemala 1075, Montevideo)
Program
- Wednesday, June 11th :: Sala Idea Vilariño - Torre de las Telecomunicaciones
-
Session 1 :: Chair : Laura Castro, MD, PhD and Valeria Valez, PhD
9:30-10:10 Mitochondrial-derived carbon dioxide and peroxide metabolism - Rafael Radi, MD, PhD
10:15-10:55 Mitochondria without oxygen: Biochemical adaptations for the normoxia-hypoxia transition in animals - Gustavo Salinas, PhD
10:55-11:15 Coffee Break
11:15-11:55 Strategies of Mycobacterium tuberculosis during infection: A look at the virulence factor PtpA and its role as a modulator of macrophage lipid metabolism - Andrea Villarino, PhD
12:00-12:40 Mitochondria and phospholipids: a novel link to the epigenome – Janine Santos, PhD
12:40-14:00 Lunch
Session 2 :: Chair : Patricia Cassina, MD, PhD and Martin Graña, PhD
14:00-14:40 Modulation of mitochondrial Cys desulfurase NFS1 function through a specific alteration of the quaternary structure - Javier Santos, PhD
14:45-15:25 Mitochondria as a Target for the Design and Development of New Natural and Synthetic Antiplatelet Drugs - Andrés Trostchansky, PhD
15:25-15:45 Coffee Break
15:45-16:00 Morpho functionality of the mitochondrial network in blood monocytes: Insights from healthy and ALS subjects - Erik Winiarski, MD, PhD student
16:05-16:35 A 10-year odyssey of a patient, his family & an interdisciplinary team to confirm the diagnosis of an atypical treatable IEM clinical case - Alfredo Cerisola, MD
16:35-18:00 Posters and coffee
- Thursday, June 12th :: Sala Idea Vilariño, Torre de las Telecomunicaciones
-
Session 3 :: Chair : Adriana Cassina, PhD and Inés Marmisolle, PhD
9:30-10:10 Alternative Splicing of the mitochondrial fission protein Drp1/DNM1L - Functional consequences on normal physiology and cancer - Nadine Hempel, PhD
10:15-10:55 Mitochondrial transfer in hematological malignancies - Natalia de Isla, PhD
10:55-11:15 Coffee Break
11:15-11:30 Mitofusin 1 Silencing Reduces SASP and Enhances Immune Response in Chemotherapy-Treated Melanoma - Jennyfer Martínez, PhD
11:35-11:50 Endo180 mediated OxPhos activation by matrix stiffness - Lucía Pastro, PhD
11:55-12:35 Orchestrating Cell Fate: The Role of Endoplasmic Reticulum to Mitochondria Calcium Transfer in Cancer and Senescence - Cesar Cardenas, PhD
12:20-14:00 Lunch
Session 4 :: Chair : Celia Quijano, PhD and Carlos Escande, PhD
14:00- 14:40 Decoding senescent lipid accumulation: Implications for healthy aging - Diana Jurk, PhD
14:45-15:15 Preclinical and Clinical study of a new anti-obesity drug developed in Uruguay - Karina Cal, PhD student
15:15-15:30 Interaction of human mitochondrial MST with peroxynitrite - Manuela Pose, PhD student
15:30-15:50 Coffee Break
15:50-16:25 Melanoma molecular fingerprinting revealed by hyperspectral imaging and phasor plots - Leonel Malacrida, PhD
16:30-17:10 New Insights into Mitochondrial Dysfunction and Cellular Senescence in the Aging Process - Joao Passos, PhD
17:10-18:00 Closure and Cocktail
Registration
Registration for the symposium will be open until Sunday, May 25th at 11:59 PM.
For further information, please feel free to contact us to curso_mitocondria@ceinbio.edu.uy
